5-Hydroxyomeprazole

Category: API's, Standards; Isotopic Labeled Analogues; Drug Impurities, Metabolites;
5-Hydroxyomeprazole 5-Hydroxyomeprazole
Application
Omeprazole: Uses, Interactions, Mechanism of Action | DrugBank Onlin: (Omeprazole: Uses, Interactions, Mechanism of Action | DrugBank Online, 2021)
Go.drugbank.com. 2021. Omeprazole: Uses, Interactions, Mechanism of Action | DrugBank Online. [online] Available at: <https://go.drugbank.com/drugs/DB00338> [Accessed 2 June 2021].

References:

1: Roberts J, McNaughtan ML, MacLachlan J, Hunter C, Pahl O.

Identification of the acid-induced degradation products of omeprazole and 5-hydroxyomeprazole by high-resolution mass spectrometry. Rapid Commun Mass Spectrom. 2018 Jun 30;32(12):929-941. doi: 10.1002/rcm.8120. PMID: 29569771.

2: Mach J, Wang X, Hilmer SN.

Quantification of serum levels in mice of seven drugs (and six metabolites) commonly taken by older people with polypharmacy. Fundam Clin Pharmacol. 2021 Apr;35(2):410-422. doi: 10.1111/fcp.12602. Epub 2020 Oct 14. PMID: 32813878.

3: Collares-Pelizaro RVA, Santos JS, Nonino CB, dos Reis Dias LA, Gaitani CM, Salgado W Jr.

Omeprazole Absorption and Fasting Gastrinemia After Roux-en-Y Gastric Bypass. Obes Surg. 2017 Sep;27(9):2303-2307. doi: 10.1007/s11695-017-2672-z. Erratum in: Obes Surg. 2017 Aug 24;: Erratum in: Obes Surg. 2017 Dec;27(12 ):3351. PMID: 28397104.

4: Busch D, Fritz A, Partecke LI, Heidecke CD, Oswald S.

LC-MS/MS method for the simultaneous quantification of intestinal CYP and UGT activity. J Pharm Biomed Anal. 2018 Jun 5;155:194-201. doi: 10.1016/j.jpba.2018.04.003. Epub 2018 Apr 5. PMID: 29649788.

5: Jang HH, Ryu SH, Le TK, Doan TT, Nguyen TH, Park KD, Yim DE, Kim DH, Kang CK, Ahn T, Kang HS, Yun CH.

Regioselective C-H hydroxylation of omeprazole sulfide by Bacillus megaterium CYP102A1 to produce a human metabolite. Biotechnol Lett. 2017 Jan;39(1):105-112. doi: 10.1007/s10529-016-2211-3. Epub 2016 Sep 17. PMID: 27640009.

6: Ahmad L, Iqbal Z, Nazir S, Khan A, Shah Y, Khan MI, Khan I, Khan A.

Effect of clopidogrel on the hydroxylation and sulfoxidation of omeprazole: A single dose study in healthy human volunteers. EXCLI J. 2017 Mar 22;16:321-327. doi: 10.17179/excli2016-658. PMID: 28507476.